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Another way that I've thought about this is around dimension reduction and expansion. In some cases there are so many different ways to think about an issue that a 2x2 helps you reduce an issue down to 2 dimensions. In other cases, something that looks simple (say size of an opportunity) becomes more interesting if you include another dimension (say, growth rate).

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Mathilde made her own 2x2 here to scan quickly how she feels / what to do with an object she owns: https://open.substack.com/pub/objet/p/beyond-the-inventory?r=2cys&utm_medium=ios&utm_campaign=post

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